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National R&D

UVNatP

Novel UV protective compounds from natural sources as active ingredients for sun care products

Principal Investigator
Group Leader

Pedro Leão is Principal Investigator and ERA Chair Holder in Blue Biotechnology and Bioengineering at CIIMAR, where he leads the Research Line in Marine Biotechnology and is the head of the Research Group “Cyanobacterial Natural Products”. He graduated in Biochemistry from the University of Porto in 2005 and went on to receive his MSc (2006) and PhD (2010) degrees from the same university. He undertook postdoctoral studies at CIIMAR, Scripps Institution of Oceanography and Harvard University. He became an “FCT Investigator” in 2015 and started his group at CIIMAR in 2018 after receiving an ERC Starting Grant. His research focuses on the chemistry, biosynthesis and chemical ecology of cyanobacterial natural products.

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Solar radiation, in particular from the UV region of the spectrum, is essential for many life processes, but is also detrimental for human health. Despite being the main cause of premature skin aging, eye damage and some forms of skin cancer, UV-A radiation is highly neglected in the UV sun care products, mostly by the lack of UV-A protective compounds that are amenable to be used in sunscreen formulations. The present invention refers to a group of molecules that are natural sunscreens, produced by bacteria living in environments with extreme exposure to solar radiation to protect their DNA from UV damage. These molecules can filter up to 90% of the UV-A radiation and because they are produced as a cocktail, they cover a wide range of the UV spectrum. Thus, this invention will support the development of these natural UV-protectants into highly efficient sunscreen ingredients.
This project aims at the protection through national and international patent of the invention UVNatP that, by focusing on natural products, potentially biodegradable and of low toxicity, that are stable, colorless or have only a very faint color, constitute compatible ingredients for sunscreen formulations. Furthermore, these compounds also have antibacterial activity, bringing added value for their topical application.
The international patent application will represent a competitive advantage in the search for new economic partners to support the developments needed to take UVNatP to market and to ensure an effective commercialization, stimulating the national competitiveness.

 

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