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National R&D

XANTIFOUL

Oxygenated xanthone derivatives as antifouling agents

Investigador principal

Investigador

Doutorada em Química Farmacêutica e Medicinal, Mestre em Controlo de Qualidade de Plantas e Fármacos e Licenciada em Ciências Farmacêutica pela Faculdade de Farmácia da Universidade do Porto (FFUP).
Professora Auxiliar de Química Orgânica e Medicinal na FFUP e Membro Integrado do CIIMAR desde 2014. Mentora dos Jovens Embaixadores da European Marine Board. Membro do Conselho Editorial da revista Marine Drugs.
Investigação centrada na síntese sustentável de agentes antivegetativos não tóxicos de inspiração marinha para ultrapassar os problemas ambientais associados aos biocidas e as dificuldades na produção em grande escala de produtos naturais marinhos:
-financiamento captado como Investigador Principal com o CIIMAR como proponente: PTDC/CTA-AMB/0853/2021 (€ 244.397,50) e PTDC/AAG-TEC/0739/2014 (€ 161.852,00);
-pedidos de patentes internacionais publicados como Inventor Responsável: WO/2023/053059 (06/04/2023), patente dos Estados Unidos US2021395264 AA (23/12/2021), patente europeia EP3897150 A1 (27/10/2021), patente chinesa CN113226035 A (06/08/2021), WO20128674 A1 (25/06/2020) e como co-inventor: PCT/IB2022/062027 (11/12/2022);
-prémios de inovação: BIPacceleration 2022, BIPproof 2022, UITransfer 2023.

EQUIPAS DE INVESTIGAÇÃO:
Produtos naturais marinhos e química medicinal

No results found.

The present invention refers to the discovery of oxygenated xanthones and their analogs as novel antifouling agents. Procedures to the obtention of these compounds are included. The advantages of these compounds include: their synthesis is suitable for scale-up; for most of the compounds only three steps of chemical synthesis are required from commercially available building blocks. These novel agents act by not inducing toxic effects to target and non-target species, being compatible with marine coatings, and contributing to improve coating characteristics currently being marketed, both in terms of effectiveness in prevent biofouling and toxicity to the environment.
The potential of these compounds as antifouling agents was demonstrated and validated for their low toxicity and effectiveness in preventing adhesion of the plantigrade larvae of mussel, Mytilus galloprovincialis, one of the most problematic species constituting biofouling communities. As regards its viability in the form of antifouling coatings, it was demonstrated by its incorporation in different commercial marine coatings based on polyurethane and silicon, coupled with reduced leaching behaviour, according to the ISO standard, which could promote a long-term protective effect.
The international patent application will represent a competitive advantage in the search for new economic partners to support the developments needed to take XANTIFOUL to market and to ensure an effective commercialization, stimulating the national competitiveness.

 

PROJECT SHEET

Equipas de investigação
Genómica evolutiva e bioinformática
Produtos naturais marinhos e química medicinal
Biotecnologia azul, saúde e ambiente
Instituição líder
CIIMAR-UP
Programa
Portugal 2020
Financiamento
Outros projectos